AG Prof. Dr. Georg Sczakiel Phone: (+49 451) 500-2731 Fax: (+49 451) 500-2729 email: sczakiel@imm.uni-luebeck.de

Oligonucleotides as tools and drugs: biochemistry & molecular biology

In Bearbeitung / Under construction.

Kretschmer-Kazemi Far, R., Leppert, J., Frank, K. & Sczakiel, G.
Technical improvements of the computational target search for antisense oligonucleotides.
Oligonucleotides 15, 223-233 (2005).

Overhoff,M., Alken, M., Kretschmer-Kazemi Far, R., Lemaitre, M., Lebleu, B., Sczakiel, G. & Robbins, I.
Local RNA target structure influences siRNA efficacy: a systematic global analysis.
J. Mol. Biol., 348, 871-881 (2005).

Gallo, M., Kretschmer-Kazemi Far, R., Sczakiel, G. & Iribarren, A. M.
Activity and stability of hammerhead ribozymes containing 2'-C-methyluridine: a new RNA Mimic.
Chem. Biodiversity, 2, 198-204 (2005).

Lehmann, M & Sczakiel, G.
Spontaneous uptake of biologically active recombinant DNA by mammalian cells
via a selected double-stranded DNA segment.
Gene Ther., 12, 446-51 (2005).

Wünsche, W. & Sczakiel,G.
The biological activity of siRNA is related to the kinetics of siRNA-target RNA recognition in vitro: mechanistic implications.
J. Mol. Biol., 345, 203-209 (2005).

Overhoff, M., Wünsche, W. & Sczakiel, G.
Quantitative detection of siRNA and single-stranded oligonucleotides:
relationship between uptake and biological activity of siRNA.
Nucleic Acids Res., 32, e170 (2004).

Kretschmer-Kazemi Far, R. & Sczakiel, G.
The activity of siRNA in mammalian cells is related to structural target accessibility:
a comparison with antisense oligomucletides.
Nucleic Acids Res., 31, 4417-4424 (2003).

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